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Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of several active ingredient, that might make them more efficient and safer. Combo-pilling will be the newest fad or also the newest ahead under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular may be the fact that by right now there are no long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure level and pulse rate, and must not be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and heartbeat and must not used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. 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